Drugs to lower high blood pressure and cholesterol were most commonly involved, the data showed.
The authors base their findings on a study looking at people of working age who died or required admission to hospital within 48 hours of an unintentional fall at home in Auckland, New Zealand, between 2005 and 2006.
In all, there were 344 such cases during the study period, and these were compared with 352 people randomly selected from the electoral register, matched for age and sex. Taking prescription medicines emerged as a risk factor for injury associated with an unintentional fall.
Those taking two or more were 2.5 times as likely to sustain an injury as a result of an unintentional fall as those on fewer.
The findings held true, even after taking account of personal, social, and lifestyle factors, including hazardous drinking, illicit drug use, and sleep quotient in the previous 24 hours.
Of the six classes of medicines for which there were sufficient numbers for analysis, drugs to lower blood pressure and cholesterol seemed to triple the risk of a fall. No increased risk was found for asthma inhalers, anti-inflammatories, steroids, or antidepressants.
It was not clear if these effects related to the drugs themselves or to the underlying conditions they were being used to treat.
Falls are a leading cause of injury and death around the world, say the authors, adding that most research on the topic, to date, has focused on children and older adults.
And they conclude that their research has "revealed a largely unrecognised problem among this younger age group.
Notwithstanding the limitations of this study, the findings signal a need for greater awareness of the association between prescription medications and falls in younger adults, whether this is due to the medications, underlying conditions or a combination of both related factors," they write.
