Pulse flow oxygen administered during early inspiration is a promising approach to oxygen conservation. Previous short-term studies show equivalent arterial P02, 55 to 60 percent oxygen savings, and no reduction of nasal humidity when compared with continuous flow nasal cannula oxygen.
This study compares the clinical efficacy of pulse flow and continuous flow oxygen in 100 patients recently hospitalized for diseases requiring 02 therapy. In an unblinded crossover design. pulse and continuous 02 were administered alternately during four 51/2-hour periods.
Oxygen saturation was monitored continuously during the 23- hour study. Mean Sa02 on pulse flow (95.6 +1- 2.7 percent) was clinically the same as continuous flow (95.3 +1- 2.6 percent). Mean Sa02 on pulse flow during the 30 minutes before or after each crossover (95.5 +I- 3.3 percent) was similar to continuous flow during the 30 minutes near crossover (95.3 +/- 3.1 percent).
It is concluded that the two delivery systems produce similar levels of Sa02 over the course of a day and night. Analysis of potential cost savings achieved by use of the device for a 350-bed hospital suggests a savings of about 550.000 yearly when accompanied by termination of oxygen humidification.