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Hair loss or Androgenic Alpecia

Supplier: Clear Skincare
01 June, 2007

Androgenetic alopecia (AGA) is the medical name for the most common form of hair loss affecting both men and women. It affects around 50% of men and between 20% - 50 % of women by the age of 50.

AGA is caused by progressive, gradual shrinking of normal hair follicles that produce normal (terminal) hairs into miniturised hair follicles that produce fine (vellus) hairs. The terminal-to-vellus hair ratio, normally 2:1 gradually reduces until it is reversed.

Although AGA is considered by most doctors to be a cosmetic condition, it can have significant psychological and physical effects on those affected by it.  Loss of hair allows increased ultraviolet light to reach the scalp and, in Australia, the highest incidence of malignant melanoma is on the scalps of balding men. AGA has also been linked to prostrate and cardiac conditions in older men.  Women are particularly prone to suffering the adverse psychological effects of hairloss, as a thick head of hair is a highly valued aspect of feminine beauty in almost every culture.

AGA occurs most commonly in Caucasian men, followed by Asian and African American men.  AGA has it’s lowest incidence in Native American and Eskimo men.  Almost all men and women with AGA begin to loose their hair prior to the age of 40 and many will commence loosing their hair by the age of 30.  AGA is distinguished from all other types of Alopecia by it’s gradual onset.

Men present with gradual thinning in the temporal areas, producing a V shaped frontal hairline.  As baldness progresses, a bald patch appears on the crown of the head, which increases in size as the frontal hairline recedes.  Eventually the receeding frontal hairline and the bald patch meet up, leading to loss of hair on most of the top of the head, whilst the hair around the base of the head remains intact. This pattern of hair loss is classified by doctors as Norwood/Hamilton stages 1-7.

Women usually present with diffuse thinning of hair on the crown of the head. This pattern of hair loss is classified by doctors as Ludwig stages 1-3.  V shaped temporal recession does occur in women but usually to a lesser degree than in men.  In general, women maintain their frontal hairline.

AGA is inherited however, the exact mechanism of inheritance has not been determined.  It is also likely that systemic or external factors play a role.  There are currently only 2 clinically proven, TGA/FDA–approved medications available for treatment of AGA - Minoxidil and Finasteride.

Minoxidil
Although the exact mechanism of action is unknown, Minoxidil appears to lengthen the duration of the anagen ( growth ) phase of hair, and it may increase the blood supply to the follicle.  Used alone, regrowth is more pronounced on the crown than in the frontal scalp and is not noted for at least 4 months.  Consequently, many people grow discouraged and give up using Minoxidil before it has had a chance to work.
 
Clearskincare’s Novaderm Skin & Scalp Roller offers a safe, effective and affordable way to maximise the beneficial results of Minoxidil.  Best of all, results can be achieved within 4-6 weeks with daily scalp rolling and a single application of Minoxidil.

Treatment with Minoxidil and the Novaderm Skin & Scalp Roller is undertaken indefinitely, as stopping treatment leads to reversion to the pretreatment balding pattern.

Finasteride
Finasteride is taken orally and is a 5 alpha-reductase type 2 inhibitor.  It is not an antiandrogen. The drug can be used only in men.  Finasteride has been shown to diminish the progression of ALA in males who are treated, and to stimulate hair regrowth.

Finasteride must be continued indefinitely because discontinuation results in gradual progression of the disorder.

In women with ALA, especially those with a component of hyperandrogenism (see Polycystic Ovarian Syndrome explanation in the Clearskincare website), drugs that act as androgen suppressants (eg, spironolactone and oral contraceptives) may be beneficial.  Surgical treatment of ALA has been performed for the past 4 decades via Hair Transplantation.  The main problem is covering the bald area with sufficient donor plugs to produce a normal hair pattern.  Micrografting produces a more natural appearance than the old technique of transplanting plugs.  Scalp reduction has been attempted to decrease the size of the scalp to be covered by transplanted hair.  However, the scars produced by the reduction technique often spread and become more noticeable with time.

Ideally, if treatment with Minoxidil and the Novaderm Skin & Scalp Roller is commenced as soon as hair loss becomes apparent, the need for surgical treatment can be prevented.