25 November, 2008
QuikClot 1st Response™ & QuikClot ACS+™, provide first responder and military users with the ability to stop severe bleeding at the scene safely and effectively.
With its new QuikClot 1st Response™ and QuikClot ACS+™ products, the company has removed the only potential side effect of its lifesaving invention – the possible generation of excess heat in certain circumstances – while retaining 100% product efficacy.
The new products give military and first responder users the ability to save lives by stopping severe bleeding right at the scene of a bleeding incident, without concern that they might cause burning.
With this breakthrough, Z-Medica expects that its cooler products will be even more rapidly adopted by law enforcement, firefighters, EMTs, environmental health & safety teams and industrial nurses, as well as more widely deployed by the military and homeland security organizations. Solving the heat issue also opens the door to development of QuikClot(r) products for use in surgical and other medical applications – in response to growing requests from medical professionals worldwide for new hemostatic capabilities.
QuikClot 1st Response™ and QuikClot ACS+™ take advantage of the delivery system introduced last year in the company's second product, QuikClot ACS™ (Advanced Clotting Sponge).
In these products, QuikClot? is formulated into beads enclosed in a porous surgical fabric. When introduced into a wound, this sponge takes the shape of the injury, conforms to the wound and rapidly stops even the most severe venous and arterial bleeding.
The sponge stays in place and is easily removed in the surgical setting. QuikClot ACS+™ is intended for use in larger wounds and QuikClot 1st Response™ is for use in the types of wounds generally encountered by first responders. Larger wounds can also be treated by using more than one QuikClot 1st Response™ sponge.
“Eliminating the potential of excessive heat being created during QuikClot(r) usage has been the number one focus of our company for the past two years,” said Z-Medica CEO Raymond J. Huey.
“With more than a million packets of QuikClot(r) deployed within all branches of the U.S. military and first responders, we've developed a track record of proven success in stopping the most severe bleeding in many environments -- resulting in many lives saved,” Huey said. “By eliminating the potential of excessive heat generation with improper use, we expect to remove any hesitation about using these products – and to save many more lives.”
To resolve the heat issue while retaining product efficacy, Z-Medica reached out to scientific experts in both the military and the private sector. These included zeolite expert Professor Galen Stucky and his team, including Todd Ostomel, at the University of California Santa Barbara, the Office of Naval Research and the Naval Medical Research Center. The latter two were testing and development partners in earlier QuikClot? formulations.
“While we have found that we could eliminate the heat altogether, we've learned that a little heat can be a good thing,” Huey reported. “Heat can accelerate coagulation, so we have optimised this parameter in terms of eliminating risks and maximising efficacy. We have specified the product to have a maximum temperature in use of less than 120o F. In testing, we have seen typical maximum temperatures in vivo of 105o F. This is a comfortable temperature range that would only be attained for a matter of a minute or so before dissipating.”
Ultimately, Z-Medica incorporated research and testing assistance from a number of resources to develop its own proprietary formulas that, like earlier versions of QuikClot?, are safe, effective and very cost effective -- and now, also eliminate the heat issue.