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Novocastra Antibodies - B Cell Specific Octamer Binding Protein-1 (BOB-1)

Supplier: Leica Microsystems Melbourne

Liquid Monoclonal (NCL-L-BOB-1)

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Clone TG14

B cell specifi c octamer binding protein-1 (BOB-1) is a lymphocyte specifi c transcriptional coactivator protein.

It interacts with OCT1 and OCT2 transcription factors and is also reported to co-express with high levels of Bcl-6.

Studies have shown over expression of the BOB-1 antigen may play a role in the pathogenesis of germinal center derived B cell lymphoma*.

* Greiner A, Muller KB, Hess J, et al. Up-regulation of BOB.1/OBF.1 expression in normal germinal center B cells and germinal center-derived lymphomas. Am J Pathol.2000 Feb;156(2):501-7.

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