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Semi-Synthetic Prodrug | Ceftaroline Fosamil

Supplier: AstraZeneca Australia

Ceftaroline Fosamil is a semi-synthetic prodrug from the cephalosporin class of β-lactam antibiotics.

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Features of Ceftaroline Fosamil Semi-Synthetic Prodrug:

  • The solubility of ceftaroline fosamil in water is 8.6 mg/mL.
  • Its solubility is increased in the intravenous (IV) infusion by inclusion of L-arginine as an alkalising agent.
  • The pH of the IV infusion is in the range of 5.0 to 7.0.
  • Ceftaroline has one strongly acidic proton and one moderately acidic proton on the phosphoamino group (pKa 1.22 and 5.10), a strongly acidic carboxylic acid group (pKa 1.79) and a pKa associated with the secondary amide adjacent to the β-lactam (pKa 10.9).

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