Features of Ceftaroline Fosamil Semi-Synthetic Prodrug:
- The solubility of ceftaroline fosamil in water is 8.6 mg/mL.
- Its solubility is increased in the intravenous (IV) infusion by inclusion of L-arginine as an alkalising agent.
- The pH of the IV infusion is in the range of 5.0 to 7.0.
- Ceftaroline has one strongly acidic proton and one moderately acidic proton on the phosphoamino group (pKa 1.22 and 5.10), a strongly acidic carboxylic acid group (pKa 1.79) and a pKa associated with the secondary amide adjacent to the β-lactam (pKa 10.9).